ATPase family AAA domain-containing protein 3B (ATAD3B)

ATPase family AAA domain-containing protein 3B (ATAD3B) is a mitochondrially localized AAA+ ATPase protein anchored in the inner mitochondrial membrane, where it forms complexes with ATAD3A, modulating mitochondrial network organization and homeostasis[1][2][3]. ATAD3B is predominantly expressed in human embryonic stem cells and is re-expressed in several cancers, where it acts as a dominant negative regulator of ATAD3A, interfering with its interaction with mitochondrial nucleoid complexes and contributing to mitochondrial fragmentation[2][3]. ATAD3B belongs to a subfamily of chaperone-like AAA+ ATPases structurally related to protein remodeling factors, and has been connected to cell proliferation, stem cell pluripotency, and cancer progression[1][4]. Defects or dysregulated expression of ATAD3B are implicated in mitochondrial diseases and various malignancies, although no specific drugs or targeted therapies are currently approved for ATAD3B modulation[3]. The protein's compartmentalized structure and unique dual localization (contacting both intermembrane space and potentially cytosol) suggest roles in mitochondrial-cytosolic communication and the regulation of metabolic and genetic homeostasis within the organelle[1].

Other names

ATPase family AAA domain-containing 3BKIAA1273TOB3AAA-TOB3ATAD3BAAA-ATPase TOB3ATPase family AAA domain containing 3B

Not applicable (no drugs currently target ATAD3B specifically)[3]