ATPase family AAA domain-containing protein 3C (ATAD3C)

ATPase family AAA domain-containing protein 3C (ATAD3C) is a mitochondrial membrane-associated ATPase in the AAA+ superfamily, sharing homology with ATAD3A and ATAD3B. While previously considered a pseudogene product, ATAD3C is now recognized as a protein expressed in human cells, localizing to the mitochondria where it influences the structure and function of the mitochondrial inner membrane. ATAD3C modulates ATP binding and hydrolysis, affecting the assembly of mitochondrial respiratory complexes and oxidative phosphorylation, often by negatively regulating the function of ATAD3A through dominant-negative interactions. Functional disturbances in ATAD3C expression can impact mitochondrial organization, cellular proliferation, ROS production, and are associated with mitochondrial diseases and developmental syndromes. No drugs are known to directly interact with ATAD3C, and it is not currently an established therapeutic target.

Other names

ATPase family AAA domain containing 3CATAD3CFLJ34599ATPase family AAA domain-containing protein 3C