ATPase phospholipid transporting 11A (ATP11A)

ATPase phospholipid transporting 11A (ATP11A) is a P4-ATPase flippase localized in the plasma membrane, catalyzing the translocation of aminophospholipids like phosphatidylserine and phosphatidylethanolamine from the extracellular to the cytoplasmic leaflet, thereby ensuring membrane lipid asymmetry essential for cellular integrity, signaling, and morphogenesis[1][2][5][6][8]. It is directly implicated in neuromuscular development and maintaining cholesterol homeostasis. Pathogenic mutations in ATP11A can disrupt substrate specificity, cause improper localization and degradation, and result in neurological and developmental diseases[4][6][8]. The protein also participates in immune signaling pathways, and its activity may be pharmacologically relevant for certain drugs. ATP11A’s biomedical importance and clinical associations with neurodevelopmental disorders position it as a potential diagnostic biomarker and therapeutic target.

Other names

ATPIHATPISKIAA1021Phospholipid-translocating ATPasePotential phospholipid-transporting ATPase IHATPase, class VI, type 11AP4-ATPase flippase complex alpha subunit ATP11A

Drugs may target or exploit its flippase activity to alter phospholipid distribution, affecting membrane structure and cell signaling\nLonafarnib involvement may relate to modified drug uptake via altered lipid composition