ATPase phospholipid transporting 8A1 (ATP8A1)

ATPase phospholipid transporting 8A1 (ATP8A1) belongs to the P4-ATPase subclass of P-type ATPases and functions as an aminophospholipid translocase ("flippase") in cell membranes[1][5][8]. Utilizing ATP hydrolysis, ATP8A1 actively flips phosphatidylserine and phosphatidylethanolamine from the outer to the inner leaflet, maintaining membrane lipid asymmetry required for normal cell signaling, migration, vesicle trafficking, and phagocytosis recognition. ATP8A1 is expressed in a wide range of tissues, especially nervous tissue, and regulates key processes such as synaptic vesicle formation, endosomal trafficking, and cellular migration. Mutations or deficiency in ATP8A1 result in neurological disorders with impaired movement and cognition, underscoring its essential role in central nervous system development and function[1][2][5]. ATP8A1, together with its partner CDC50A, forms a heterodimer that cycles through conformational states to drive phospholipid translocation via a mechanism known as the Post-Albers scheme, characterized by sequential ATP binding, hydrolysis, and domain rearrangement[4]. No approved drugs target ATP8A1 directly, but its dysfunction serves as a disease model, particularly for neurodevelopmental syndromes.

Other names

ATPase phospholipid transporting 8A1ATP8A1ATPase, aminophospholipid transporter (APLT), Class I, Type 8A, Member 1ATPIAP4-ATPase flippase complex alpha subunit ATP8A1Phospholipid-transporting ATPase IAATPase class I type 8A member 1Chromaffin granule ATPase II

Not applicable; no approved drugs. Mechanisms explored in research: inhibition/modulation of ATPase/flippase activity affects lipid distribution and cell signaling[4].