ATPase phospholipid transporting 8B3 (ATP8B3)

ATPase phospholipid transporting 8B3 is a member of the P-type ATPase (P4-ATPase) family that catalyzes ATP-dependent translocation of aminophospholipids—primarily phosphatidylserine (PS)—across biological membranes, typically from the outer to inner leaflet, thus maintaining membrane phospholipid asymmetry[1][3][4][7]. In humans, it is encoded by the ATP8B3 gene on chromosome 19. ATP8B3 is particularly important for proper sperm function in mammals by regulating PS exposure during capacitation and is implicated in the fertilization process[6]. Variants in ATP8B3 have been associated with differential responses to chemotherapeutic agents such as oxaliplatin in colorectal cancer, making it of interest both as a therapeutic and biomarker target in oncology[4]. ATP8B3 belongs to a broader class of aminophospholipid translocases, many of which have emerging importance in diseases related to membrane biology, including cancer and reproductive disorders[4][6][7].

Other names

ATP8B3ATPIKProbable phospholipid-transporting ATPase IKaminophospholipid translocase type 8B member 3SAPLT (in mouse)

SNPs affecting ATP8B3 may modulate sensitivity/resistance to oxaliplatin therapy in colorectal cancer, likely through effects on cellular membrane composition or transport