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ATPase phospholipid transporting 9A (ATP9A)
- Target
- ATP9A
- Molecular classification
- Enzyme (ATPase), Transporter (flippase), P-type ATPase (Type IV, P4-ATPase)
01
Overview
ATPase phospholipid transporting 9A (ATP9A) is a type IV P-type ATPase (P4-ATPase) that localizes to early/recycling endosomes and the trans-Golgi network. It is implicated in the recycling of cargo proteins (such as transferrin receptor and glucose transporter 1) from endosomes to the plasma membrane, as well as in retrograde transport from endosomes to the Golgi apparatus. ATP9A is thought to participate in the formation of endosomal carriers, potentially by generating membrane curvature through phospholipid translocation, although its exact lipid substrate is not fully confirmed. Genetic disruptions can lead to neurodevelopmental disorders characterized by poor growth and behavioral abnormalities[1][2][5]. ATP9A is considered a putative drug target in cellular transport and development research, but approved drugs that directly target it have not been reported.
- Other names
- ATP9AATPase IIAATPIIAATPase, class II, type 9A
02
Mechanism of action
Potential small molecule modulation of endosomal recycling or flippase activity (no clinical drugs reported)
03
Biological functions
Regulation of endosomal recyclingNegative regulation of exosomal secretionEndosome to trans-Golgi network retrograde transportMembrane traffickingRegulation of neurite morphology and synaptic transmission
04
Disease associations
Neurodevelopmental disorders (e.g., intellectual disability, poor growth, behavioral abnormalities)
05
Safety considerations
Disruption may affect neuronal development, membrane trafficking, and synaptic function
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