ATPase phospholipid-transporting 9B (ATP9B)

ATPase phospholipid-transporting 9B (ATP9B) is a member of the P4-ATPase family, functioning as an ATP-dependent phospholipid "flippase" that translocates specific phospholipids from the exoplasmic to the cytoplasmic leaflet of cellular membranes[1][2][4]. Unlike most other P4-ATPases, ATP9B localizes to the trans-Golgi network and can exit the endoplasmic reticulum independently of CDC50 proteins[2][4]. ATP9B forms homo- or heteromeric complexes (notably with ATP9A) to mediate efficient vesicular trafficking, particularly in exocytic pathways between the Golgi and plasma membrane[4]. The gene is implicated in certain neurodevelopmental and hepatic disorders, and polymorphisms may modulate susceptibility to additional conditions such as skin diseases, but ATP9B is not currently a direct drug target, nor are clinically approved drugs known to interact with it[1][2][4].

Other names

Probable phospholipid-transporting ATPase IIBATPIIBNEO1LHUSSY-20ATPASEPhMMR1Macrophage MHC receptor 1Putative phospholipid-transporting ATPase IIB

Not applicable or none known (no known targeting drugs as of current evidence)