ATPase plasma membrane Ca2+ transporting 1 antisense RNA 1 (ATP2B1-AS1)

ATPase plasma membrane Ca2+ transporting 1 antisense RNA 1 (ATP2B1-AS1), also known as LINC00936, is a **long non-coding RNA (lncRNA)** located on human chromosome 12 (chr12:89,708,954–89,713,726), with a length of 3626 base pairs[1]. It is transcribed in the antisense direction relative to the ATP2B1 gene, but does not code for a protein. ATP2B1-AS1 regulates gene expression post-transcriptionally, primarily by acting as a competitive endogenous RNA (ceRNA or “miRNA sponge”). It has been demonstrated to interact with and negatively regulate microRNAs such as miR-23a-3p, and subsequently modulate important signaling pathways (e.g., TLR4/NF-κB pathway) involved in inflammation and apoptosis[1][2][3]. Dysregulation of ATP2B1-AS1 is implicated in several pathophysiological settings, including sepsis, myocardial infarction, some cancers, and diabetic retinopathy, generally promoting disease by enhancing apoptosis and inflammatory responses[1][2]. It is *not* a classical therapeutic target such as a receptor, enzyme, or transporter, but may serve as a potential biomarker or a novel target for RNA-based therapies in the future.

Other names

LINC00936long intergenic non-protein coding RNA 936ATP2B1-AS1