Atrial Natriuretic Factor Receptor B (NPR-B)

Atrial natriuretic factor receptor B, also known as natriuretic peptide receptor B (NPR-B) or NPR2, is a transmembrane receptor that primarily binds C-type natriuretic peptide (CNP). It is part of the guanylyl cyclase-coupled family of natriuretic peptide receptors. Upon binding its ligand, NPR-B catalyzes the conversion of GTP to cyclic GMP (cGMP), acting as a membrane-bound guanylyl cyclase. cGMP serves as a second messenger mediating downstream effects such as activation of cGMP-dependent protein kinases and modulation of ion channels. NPR-B plays a role in vasodilation, inhibition of vascular smooth muscle cell proliferation, regulation of atrial electrophysiology, and skeletal growth. Mutations in *NPR2* are associated with certain forms of skeletal dysplasia and may contribute to essential hypertension.

Other names

Natriuretic Peptide Receptor BGuanylyl Cyclase-BGC-BNPRBNPR2

Binding of CNP leading to activation of guanylyl cyclase and increased cGMP production.