Atrial natriuretic peptide receptor 1 (NPR1)

Atrial natriuretic peptide receptor 1 (NPR1), also known as natriuretic peptide receptor A (NPRA) or guanylyl cyclase A (GC-A), is a membrane-bound receptor that primarily binds atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP). These peptides are potent vasoactive hormones crucial for cardiovascular homeostasis, regulating blood pressure, blood volume, and sodium balance. NPR1 functions as a guanylyl cyclase, converting GTP to cGMP upon ligand binding, leading to downstream effects like vasodilation.

Other names

NPRAGC-AGuanylyl cyclase AAtrial natriuretic peptide receptor A

Ligand binding to NPR1 activates guanylyl cyclase, increasing cGMP levels, activating PKG, and leading to vasodilation.