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Target intelligence / Profile preview
Atrial Natriuretic Peptide Receptor 2 (NPR2)
- Target
- NPR2
- Molecular classification
- Receptor, Enzyme, Guanylyl cyclase, Transmembrane receptor
01
Overview
Atrial natriuretic peptide receptor 2 (NPR2), also known as natriuretic peptide receptor B (NPR-B) or guanylate cyclase B (GC-B), is a membrane-bound receptor that primarily binds C-type natriuretic peptide (CNP). Upon ligand binding, it catalyzes the conversion of GTP to cGMP, a second messenger involved in skeletal growth regulation and potentially other homeostatic processes. Mutations in the NPR2 gene can lead to skeletal dysplasias.
- Other names
- Natriuretic peptide receptor BANP-BANPR-BANPRBAtrial natriuretic peptide receptor type BGC-BGuanylate cyclase BNPR-B
02
Mechanism of action
Guanylate cyclase activation leading to increased cGMP production
03
Biological functions
Signal transductionRegulation of skeletal growthcGMP signaling pathwayEndochondral ossification
04
Disease associations
Skeletal dysplasiaDisproportionate dwarfism
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