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Target intelligence / Profile preview
Atrial Natriuretic Peptide Receptor Type B (NPRB)
- Target
- NPRB
- Molecular classification
- Receptor, Guanylyl cyclase, Transmembrane receptor
01
Overview
Natriuretic Peptide Receptor Type B (NPRB or NPR2) is an essential single-pass transmembrane receptor with intrinsic guanylate cyclase activity. It primarily binds C-type natriuretic peptide to regulate vascular tone, renal function, and skeletal development via cGMP-mediated signaling pathways. Mutations in its gene are linked to specific skeletal dysplasias.
- Other names
- Natriuretic Peptide Receptor BNPR2Guanylyl Cyclase-BGC-BANP B
02
Mechanism of action
Activation of guanylyl cyclase leading to increased intracellular cGMP levels.
03
Biological functions
VasodilationRegulation of blood pressureRegulation of sodium excretionRegulation of water balanceSkeletal growth regulationcGMP signaling
04
Disease associations
Acromesomelic Dysplasia Maroteaux typeEpiphyseal Chondrodysplasia Miura typeCardiovascular disease
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