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Atrioventricular Node (AV node)
- Target
- AV node
- Molecular classification
- Specialized Cardiac Tissue, Component of Cardiac Conduction System
01
Overview
The atrioventricular (AV) node is a specialized structure within the heart's electrical conduction system. It serves as the critical electrical connection between the atria and ventricles, ensuring coordinated contraction of these chambers for effective blood flow. The AV node delays the transmission of electrical impulses from the sinoatrial (SA) node to allow complete atrial contraction before ventricular activation. The autonomic nervous system modulates AV nodal conduction: Sympathetic stimulation increases conduction velocity, while parasympathetic stimulation decreases it. Disorders affecting AV nodal function include various degrees of heart block.
- Other names
- nodus atrioventricularisAVN
02
Mechanism of action
Modulation of AV nodal conduction velocity by altering ion channel activity or autonomic nervous system influence.
03
Biological functions
Electrical conduction between atria and ventriclesDelay of impulse conductionSecondary pacemakerUnidirectional excitation flow
04
Disease associations
Heart blockConduction disordersEbstein's anomaly
05
Safety considerations
BradycardiaHypotensionHeart block
06
Interacting drugs
Beta-blockers
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