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Target intelligence / Profile preview
AType-1 Angiotensin II Receptor (AT1)
- Target
- AT1
- Molecular classification
- G protein-coupled receptor
01
Overview
The AType-1 angiotensin II receptor (AT1) is a G protein-coupled receptor (GPCR) that plays a central role in the renin–angiotensin–aldosterone system (RAAS). It is the primary receptor mediating the effects of angiotensin II, including vasoconstriction, aldosterone release, and cardiac hypertrophy. It is a major target for drugs used to treat hypertension and other cardiovascular diseases.
- Other names
- Angiotensin II type 1 receptorAT1RAGTR1
02
Mechanism of action
Angiotensin II receptor blockers (ARBs) antagonize selective facets of AT₁R function depending on their pharmacological properties. They block the binding of angiotensin II to the AT1 receptor, thereby inhibiting its downstream effects.
03
Biological functions
VasoconstrictionAldosterone synthesis/secretionIncreased vasopressin secretionCardiac hypertrophyAugmentation of peripheral noradrenergic activityVascular smooth muscle cell proliferationDecreased renal blood flowRenal renin inhibitionModulation of central sympathetic outflowCardiac contractility regulationCentral osmocontrolExtracellular matrix formationStimulation of drinking behavior
04
Disease associations
HypertensionDiabetic nephropathyCongestive heart failureCardiovascular diseases
05
Safety considerations
Genetic polymorphisms in AGTR1 may alter drug efficacy or disease susceptibility.
06
Interacting drugs
Angiotensin II receptor blockers (ARBs)
07
Biomarkers
Genetic polymorphisms in AGTR1 may alter drug efficacy or disease susceptibility due to changes in expression or function of the receptor.
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