Atypical chemokine receptor 5 (ACKR5)

Atypical chemokine receptor 5 (ACKR5), commonly known as G protein-coupled receptor 182 (GPR182), is a member of the atypical chemokine receptor family within the larger GPCR superfamily. Unlike canonical chemokine receptors, it does not transmit classical G-protein-dependent intracellular signals upon ligand binding, but instead serves as a scavenger receptor for multiple chemokines, including CXCL10, CXCL12, CXCL13, and CCL28[1][2]. ACKR5 is broadly expressed in endothelial cells of blood and lymphatic vasculature across various organs and has a central role in controlling chemokine levels in tissues and blood. The receptor regulates immune cell migration and tissue organization by shaping chemokine gradients, and its deficiency leads to dysregulated chemokine levels, hematopoietic stem cell egress from the bone marrow, and altered splenic architecture. As of the current literature, no drugs are approved to specifically modulate ACKR5/GPR182 activity[1][2].

Other names

G-protein coupled receptor 182GPR182adrenomedullin receptorAM-RADMRhrhAMRG10D7TMRL1-Rgamrh

Scavenging/binding of chemokines (e.g., CXCL10, CXCL12, CXCL13, CCL28) without inducing classical G-protein signaling; reduces local and systemic concentrations of these chemokines by internalization and degradation[1][2].