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Target intelligence / Profile preview
Atypical protein kinase C iota (PKCι)
- Target
- PKCι
- Molecular classification
- Enzyme, Serine/threonine-protein kinase
01
Overview
Atypical protein kinase C iota (PKCι) is a serine/threonine kinase belonging to the atypical PKC family. It plays a role in cell proliferation, differentiation, survival, and apoptosis, and regulates microtubule organization. PKCι is a bona fide human oncogene, required for transformed growth of cancer cells, making it an attractive therapeutic target. Inhibitors targeting its oncogenic signaling are under clinical investigation for cancers such as lung cancer.
- Other names
- PRKCIPKC iota type
02
Mechanism of action
Inhibition of PKCι kinase activity
03
Biological functions
Cell proliferationCell differentiationCell survivalApoptosisMicrotubule organizationSignal transduction
04
Disease associations
Cancer
05
Safety considerations
Potential for off-target effectsResistance mechanisms
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