Target intelligence / Profile preview

Aurora A Kinase (AURKA)

Target: AURKA
Molecular classification: Enzyme, Serine/threonine kinase

Overview

Aurora A kinase is a serine/threonine protein kinase essential for cell cycle regulation, particularly during mitosis and meiosis. It plays critical roles in centrosome maturation and separation, spindle assembly and stability, and microtubule nucleation. Overexpression or dysregulation of Aurora A is observed in many human cancers, making it a significant target for anti-cancer drug development.

Other names: Serine/threonine-protein kinase 6STK6

Mechanism of action

Aurora A kinase inhibitors (developmental)

Biological functions

Cell cycleCentrosome maturationSpindle assemblyMicrotubule nucleation

Disease associations

Cancer

Safety considerations

Genetic instabilityPotential for off-target effects due to kinase family homology

Beyond the preview

Go deeper on Aurora A Kinase (AURKA).

Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.

Drug pipeline

Explore the programs pursuing this target and their development progress.

Drug candidates
Developers
Development stage

Clinical trials

Follow the clinical studies evaluating therapies directed at this target.

Trial design
Status
Readouts

Competitive landscape

Compare approaches across drug candidates, modalities, and indications.

Programs
Modalities
Indications

Literature & evidence

Investigate the research and source evidence behind target biology and development.

Publications
Sources
Analysis

Patents

Explore patent activity around therapies and technologies addressing this target.

Patents
Assignees
Technologies

Research & analysis

Connect target biology, drug development, and emerging evidence in your research.

Biology
Development news
Analysis

Bring the full picture into focus.

See how Gosset can support your research on Aurora A Kinase (AURKA).

Explore the full profile