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Target intelligence / Profile preview
Serine/threonine-protein kinase Aurora (Aurora kinase)
- Target
- Aurora kinase
- Molecular classification
- Enzyme, Protein kinase, Serine/threonine kinase
01
Overview
Serine/threonine-protein kinase Aurora refers to a family of highly conserved serine/threonine kinases essential for regulating mitosis and meiosis in eukaryotic cells. The family includes Aurora A (AURKA), Aurora B (AURKB), and Aurora C (AURKC). These kinases play crucial roles in centrosome maturation, spindle assembly, and chromosome segregation. Dysregulation, particularly overexpression of AURKA, is linked to various cancers, making them attractive targets for cancer therapy. They are regulated by phosphorylation and cofactor binding. Targeting these kinases aims to disrupt cancer cell division, but safety concerns regarding toxicity and off-target effects remain.
- Other names
- Aurora AAURKASTK6Aurora 2Aurora BAURKBAurora 1Aurora CAURKC
02
Mechanism of action
Kinase inhibition
03
Biological functions
Cell cycleMitosisMeiosisCentrosome maturationSpindle assemblyChromosome segregation
04
Disease associations
CancerGenetic instabilityTumorigenesis
05
Safety considerations
Potential for off-target effects due to kinase family similarityToxicity related to cell cycle disruption
06
Biomarkers
AURKA overexpression (prognostic marker in some cancers)
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