Aurora kinase A interacting protein 1 pseudogene

Aurora kinase A interacting protein 1 pseudogene (LOC646012, ENSG00000185296) is a non-coding genomic locus that resembles the real gene encoding Aurora kinase A interacting protein 1 but harbors disabling mutations (such as premature stop codons or frameshifts), and therefore does not encode a functional protein. Pseudogenes can be transcribed, and their RNA products may exert regulatory functions such as acting as microRNA decoys or influencing expression of related genes through RNA interference pathways. However, unlike canonical protein-coding genes, this pseudogene is neither a receptor, enzyme, transporter, nor a true molecular therapeutic target. It is not implicated in direct biological pathways as a functional protein and is not characterized by molecular families such as kinases, channels, or transcription factors. Pseudogenes as a class can modulate gene expression by interacting with the RNA machinery, potentially affecting the levels of parental protein-coding genes, but such functions are not universally established for every pseudogene, and specific roles for LOC646012 have not been described. There are no known drugs, biomarkers, or safety concerns directly involving this pseudogene. In summary, Aurora kinase A interacting protein 1 pseudogene is not an actual drug target, but a non-coding gene locus with potential (yet unproven) regulatory RNA functions.

Other names

LOC646012ENSG00000185296Aurora kinase A interacting protein 1 pseudogene