Aurora kinase A pseudogene

Aurora kinase A pseudogene (ENSG00000242261) is a non-functional genomic sequence that shares sequence similarity with the protein-coding *Aurora kinase A* gene but does not code for a functional protein product[1][3]. Pseudogenes arise from gene duplication or retrotransposition events; while they may possess some sequence conservation, they generally lack biological function, clinical relevance, or direct therapeutic interest. Therefore, this pseudogene is not considered a therapeutic target. Key notes: - The *Aurora kinase A* pseudogene is distinct from the functional *Aurora kinase A* (AURKA) enzyme, which is a serine/threonine kinase involved in mitosis, oncogenesis, and targeted by specific anticancer drugs[2][5]. - The *pseudogene* itself has no reported biological activity, disease association, or role in drug interaction, and does not qualify as a target for pharmacological intervention or biomarker development[1][3]. - Some confusion can arise because pseudogenes may be listed in gene databases with similar names to their functional counterparts, but only the protein-coding gene (e.g., AURKA, not its pseudogene) is a validated therapeutic target[1][3][5]. If you are seeking information about the functional Aurora kinase A, use "Aurora kinase A" or the gene symbol "AURKA" (e.g., ENSG00000178999) instead of the pseudogene designation.

Other names

LOC100418961ENSG00000242261Aurora kinase A pseudogene