Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Aurora kinase B (AURKB)
- Target
- AURKB
- Molecular classification
- Serine/threonine kinase, Protein kinase
01
Overview
Aurora kinase B (AURKB) is a serine/threonine protein kinase crucial for regulating mitosis and cytokinesis. As a core component of the chromosomal passenger complex (CPC), it orchestrates chromosome alignment, segregation, and cytokinesis. AURKB ensures accurate chromosome segregation by regulating kinetochore-microtubule attachments and correcting errors. Overexpression or dysregulation of AURKB leads to chromosomal instability and is frequently observed in cancer, making it a therapeutic target.
- Other names
- ARK2STK12Aik2Ipl1
02
Mechanism of action
Aurora kinase B inhibitor
03
Biological functions
Cell cycleChromosome segregationKinetochore functionCytokinesisSpindle assembly checkpoint
04
Disease associations
CancerHematologic malignanciesNK-cell enteropathy
05
Safety considerations
Potential for chromosomal instability if not properly targetedToxicities associated with cell cycle disruption
06
Interacting drugs
Barasertib
1 more in the full profile.
Beyond the preview
Go deeper on Aurora kinase B (AURKB).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Aurora kinase B (AURKB).