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Aurora kinase B pseudogene

Molecular classification
Other (Pseudogene)
01

Overview

The aurora kinase B pseudogene (ENSG00000271357) is a nonfunctional genomic sequence related to the aurora kinase B gene. Like other pseudogenes, it does not encode a functional protein product due to mutations or gene disruptions that have accumulated over evolutionary time. Pseudogenes can sometimes be transcribed into noncoding RNAs that may influence the regulation of their parent genes, but they are not conventional molecular targets for drug development or disease treatment[2][1]. In summary, ENSG00000271357 is not a druggable target and should not be considered a functional gene or protein for therapeutic purposes. If the intention was to find information on the active enzyme "Aurora kinase B," the correct entity would be "Aurora kinase B" (AURKB), which is a serine/threonine kinase involved in mitosis and a cancer therapy target, but ENSG00000271357 pertains to a nonfunctional pseudogene instead[2].

02

Biological functions

Other (May occasionally be transcribed into non-coding RNA or influence gene regulation, but not known for canonical molecular functions)
03

Disease associations

Other (Pseudogenes in general may have regulatory effects in cancer or other diseases, but no direct disease associations or roles have been established for this specific pseudogene)

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