Aurora kinase B pseudogene 1 (AURKBP1)

Aurora kinase B pseudogene 1 (AURKBP1) is a non-coding pseudogene related to the aurora kinase B (AURKB) gene. Pseudogenes are genomic DNA sequences similar to normal genes but are nonfunctional; they may arise from gene duplication or retrotransposition events. AURKBP1 does not encode an active enzyme or receptor protein, nor does it have direct functional roles in cell cycle or cancer, unlike the functional aurora kinase B. There is no evidence supporting its involvement as a direct therapeutic target, nor are there known interacting drugs or established disease associations. Some pseudogenes can have subtle regulatory functions at the RNA level, but there are no known biological or pharmacological roles for AURKBP1 specifically. Important context: This entry is often confused with the true aurora kinase B (AURKB), an enzyme with essential roles in mitosis/cell cycle and significant involvement in cancer biology, which is a validated therapeutic target. AURKBP1 is a pseudogene as noted in authoritative sources, and no data indicate it encodes an active protein or functions as a target for drugs or diagnostics. If you are seeking information about the active kinase (therapeutic target), you should refer to aurora kinase B (AURKB), which is involved in cell cycle regulation, is overexpressed in cancer, and is targeted by several kinase inhibitors in clinical research and therapy.

Other names

AurBps1AURKBPS1