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Aurora Kinase C
- Molecular classification
- Enzyme, Serine/threonine kinase, Protein kinase
01
Overview
Aurora kinase C (AURKC) is a serine/threonine protein kinase that plays a crucial role in regulating cell division, particularly during meiosis. It is essential for proper chromosome segregation and cytokinesis in spermatogenesis. Aberrant overexpression has been observed in several cancer cell lines, suggesting a potential role in oncogenesis.
- Other names
- AIK3ARK3Aurora 3Serine/threonine-protein kinase 13STK13
02
Mechanism of action
Aurora kinase inhibitor
03
Biological functions
Cell cycleChromosome segregationCytokinesisMeiosisSpermatogenesis
04
Disease associations
Male infertilityCancer
05
Safety considerations
Potential for off-target effects due to homology with Aurora BInhibition of other kinases
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