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Autoimmune response

Overview

"Autoimmune response" refers to an abnormal immune reaction in which the immune system attacks the body's own healthy tissues, due to a breakdown in self-tolerance. This response features loss of immune tolerance, aberrant activation of T and B lymphocytes, and production of autoantibodies or cytotoxic cellular responses against self-antigens. Such activity underlies various autoimmune diseases, which may affect specific organs or multiple systems.

Other names: autoimmune reactionself-reactive immune responseself-directed immune response

Biological functions

Immune responseloss of self-toleranceinflammation

Disease associations

Autoimmune diseaseinflammationautoimmunity continuumnon-infectious inflammatory disease

Safety considerations

Not applicable; no direct interventions against the process itself, but drug therapies for autoimmune diseases broadly can lead to increased infection risk, immunosuppression, or organ toxicity

Biomarkers

Autoantibodies (used to diagnose and classify autoimmune diseases but not specific to a single "autoimmune response")aberrant T cell or B cell profiles

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