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Autologous Chondrocyte
- Molecular classification
- Cell
01
Overview
Autologous chondrocytes are cartilage-producing cells (chondrocytes) harvested from a patient’s own body and used in regenerative procedures, most notably autologous chondrocyte implantation (ACI), to repair articular cartilage defects. The term "autologous" indicates that the cells originate from the same individual who will receive them, eliminating risks of immune rejection. They synthesize and maintain the extracellular matrix (ECM) of cartilage, which is rich in collagen type II, aggrecan, and other proteoglycans.
- Other names
- ChondrocyteAutologous cartilage cells
02
Mechanism of action
Cells are implanted to regenerate damaged cartilage tissue by producing new extracellular matrix.
03
Biological functions
Cartilage matrix synthesisCartilage maintenanceExtracellular matrix production
04
Disease associations
Cartilage defectsOsteoarthritis (potential role in treatment)
05
Safety considerations
Graft hypertrophyGraft delamination/failureJoint adhesions/arthrofibrosisProgression to osteoarthritis
06
Interacting drugs
Fibrin glue
2 more in the full profile.
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