Automated basal and bolus insulin adjustment based on continuous interstitial glucose measurement (AID system)

The entry "Automated basal and bolus insulin adjustment based on continuous interstitial glucose measurement" does **not** refer to a single molecule, receptor, enzyme, transporter, or other canonical therapeutic target. Instead, it describes an **integrated medical technology**—commonly known as an automated insulin delivery (AID) system or hybrid closed-loop system—that combines three main components: * A **continuous glucose monitor** (CGM), which measures interstitial fluid glucose levels in real time. * An **insulin pump**, which delivers both basal and bolus doses of subcutaneous insulin. * A **control algorithm**, which processes CGM data to automatically adjust the rate of basal and sometimes correctional bolus insulin delivered by the pump[1][2][3][5]. These systems are designed to mimic some functions of the healthy pancreas ("artificial pancreas") by automating much of the day-to-day decision-making required for intensive diabetes management. They are primarily used for people with type 1 diabetes but have also shown benefit in type 2 diabetes requiring intensive therapy[4]. The user typically still needs to manually enter carbohydrate intake before meals; fully automated systems without any manual input are not yet standard. Because this is a description of a *device-based therapeutic approach*, not a molecular entity or biological target amenable to drug binding/modulation, it should be flagged as "not a target" per your conventions. If you need structured information about specific molecules involved—such as the human *insulin receptor*, *GLUT transporters*, etc.—please specify those targets instead.

Other names

Automated insulin delivery systemHybrid closed-loop systemArtificial pancreasAutomated insulin dosing (AID) systemClosed-loop insulin delivery system

Algorithm-driven adjustment of basal and bolus insulin delivery based on continuous interstitial glucose measurements from a CGM[1][2][5].