Autophagy-lysosome machinery (null)

The autophagy-lysosome machinery refers to the coordinated network of proteins, molecular complexes, and organelles responsible for intracellular degradation and recycling of cellular components through autophagy. This process involves the formation of autophagosomes, which encapsulate cytoplasmic material and then fuse with lysosomes for degradation. The lysosomal compartment contains hydrolytic enzymes that break down proteins, lipids, and organelles, enabling cellular adaptation to stress, maintenance of homeostasis, and removal of damaged or harmful material. Dysregulation of this system is implicated in various diseases, including neurodegeneration, cancer, and immune disorders[1][2][3][5][7].

Other names

Autophagy-lysosomal pathwayALPAutophagy-related pathwayLysosomal degradation machineryAutophagy machinery

Inhibition of lysosomal acidification (e.g., chloroquine, bafilomycin A1); Induction of autophagy (e.g., rapamycin via mTOR inhibition); Modulation of autophagosome-lysosome fusion; Inhibition of autophagy by blocking autophagosome maturation