Autophagy pathway regulation in renal tissue

Autophagy pathway regulation in renal tissue refers to the complex network of signaling mechanisms that control the degradation and recycling of intracellular components for cellular quality control and adaptation to stress, particularly in kidney cells. Key regulators include mTOR, AMPK, and FXR, modulating the activity of multiple autophagy-related proteins (ATG proteins, Beclin-1, LC3) in response to injury, metabolic cues, or pharmacological agents. Dysregulation of autophagy plays a vital role in the pathogenesis and progression of kidney diseases including acute kidney injury, chronic kidney disease, and renal fibrosis. However, "autophagy pathway regulation in renal tissue" is not a singular druggable target but a process involving several pathways and molecules.

Other names

Autophagy in the kidneyRenal autophagy regulationAutophagy pathway in renal tissue

Induction or inhibition of autophagy via signaling pathways (e.g., mTOR, AMPK, FXR)