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Target intelligence / Profile preview
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 (ENPP2)
- Target
- ENPP2
- Molecular classification
- Enzyme, Phosphodiesterase, Lysophospholipase D
01
Overview
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 (ENPP2), also known as Autotaxin (ATX), is a secreted enzyme with both phosphodiesterase and lysophospholipase D activity. Its main physiological function is the production of lysophosphatidic acid (LPA), a bioactive lipid that acts through GPCRs to stimulate cell proliferation, motility, chemotaxis, wound healing responses, angiogenesis, and other growth factor-like effects. ENPP2/LPA axis plays roles in tumor progression, inflammatory diseases, wound healing and bone mineralization.
- Other names
- AutotaxinATX
02
Biological functions
Cell proliferationCell migrationAngiogenesisWound healingLPA productionBone mineralizationChemotaxis
03
Disease associations
CancerInflammationAsthmaArthritisAge-related bone formation decline
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