Avibacterium paragallinarum (A. paragallinarum)

Avibacterium paragallinarum is a Gram-negative, pleomorphic, non-motile bacterium that serves as the primary causative agent of infectious coryza, an acute respiratory disease in chickens [1]. Formerly known as Haemophilus paragallinarum, this pathogen is characterized by its requirement for nicotinamide adenine dinucleotide (NAD or V-factor) for growth in vitro [2]. The disease is characterized by nasal discharge, sneezing, and facial edema, leading to significant economic losses in the poultry industry due to decreased egg production and increased culling rates [3]. While not a single molecular target itself, the bacterium contains various essential enzymes and pathways that are targeted by antimicrobial agents such as sulfonamides, tetracyclines, and fluoroquinolones [4]. Management typically involves strict biosecurity, antibiotic therapy for outbreaks, and the use of inactivated bacterin vaccines to provide serovar-specific protection [5].

Other names

Haemophilus paragallinarumInfectious Coryza agent

Inhibition of bacterial cell wall synthesis, protein synthesis, DNA replication, and folic acid metabolism