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Axin interactor, dorsalization associated (AIDA)
- Target
- AIDA
- Molecular classification
- Other (C2 domain-containing protein), Lipid-binding protein
01
Overview
Axin interactor, dorsalization associated (AIDA) is a multifunctional protein characterized by a unique C2 domain structure, enabling it to bind phosphoinositides and associate with membranes in a Ca(2+)-independent manner[1]. AIDA binds the axis formation inhibitor axin and inhibits axin-mediated Jun N-terminal kinase (JNK) activation, thereby antagonizing dorsalization during vertebrate embryonic development and promoting ventralization[1][2][3]. It plays roles in membrane dynamics, negative regulation of stress signaling pathways, and cytoskeletal anchoring. In humans, AIDA is implicated in cardiovascular disease via endothelial function regulation and may act as a biomarker in certain cancers, although there is no current evidence of it being targeted by drugs or serving as a direct therapeutic target[2][3].
- Other names
- Axin interaction partner and dorsalization antagonistC1orf80FLJ12806AIDA_HUMAN
02
Biological functions
Negative regulation of JUN kinase (JNK) activityMembrane association and phosphoinositide bindingRegulation of embryonic dorsoventral patterning (ventralization)Regulation of signaling networks and cellular stress responses
03
Disease associations
Cancer (expression linked to tumorigenesis in keratocystic odontogenic tumors)Cardiovascular disease (identified as a candidate gene influencing coronary artery disease risk via endothelial dysfunction)Other (cellular organization, developmental signaling pathways)
04
Biomarkers
Candidate biomarker in keratocystic odontogenic tumors[2]
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