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Target intelligence / Profile preview
AXL Protein Tyrosine Kinase (AXL)
- Target
- AXL
- Molecular classification
- Receptor Tyrosine Kinase (RTK), TAM RTKs, Protein Kinase
01
Overview
AXL is a receptor tyrosine kinase belonging to the TAM (TYRO3, AXL, MER) family. It is activated by its ligand GAS6, leading to receptor dimerization, autophosphorylation, and activation of downstream signaling pathways including PI3K/AKT/mTOR, RAS/MAPK, NF-κB, and JAK/STAT. AXL plays a crucial role in cell proliferation, survival, migration, invasion, and immune modulation, and is frequently overexpressed in various cancers, where it promotes tumorigenesis and drug resistance. Targeting the Gas6/AXL axis is being explored as a therapeutic strategy in cancer.
- Other names
- UFOJTK11Tyro7AXL receptor tyrosine kinaseGrowth Arrest-Specific Protein 6 Receptor
02
Mechanism of action
Kinase inhibition; receptor dimerization inhibition; blocking GAS6 binding; downstream effector inhibition
03
Biological functions
Cell proliferationCell survivalCell migrationCell invasionApoptosis inhibitionAngiogenesisImmune modulationSignal transductionActin cytoskeleton remodelingEpithelial-to-mesenchymal transition (EMT)
04
Disease associations
CancerDrug resistanceInflammationTumorigenesis
05
Safety considerations
Potential for off-target effects due to kinase family similarityDevelopment of resistance mechanismsImmune-related adverse events
06
Biomarkers
AXL expression level in tumor tissueGAS6 expression level in tumor microenvironment
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