Axonemal dynein light chain domain-containing protein 1 (AXDND1)

Axonemal dynein light chain domain-containing protein 1 (AXDND1) is a protein-coding gene primarily expressed in the testis and is essential for spermiogenesis and male fertility in mammals[1][2][7]. It is predicted to function in regulating manchette dynamics, spermatid head shaping, and assembly of the sperm flagellum, likely by participating in protein and vesicle transport along microtubules[1][2]. Disruption of AXDND1 in mouse models leads to male sterility, abnormal sperm structures, and defective sperm motility, with similar pathogenic variants associated with human azoospermia[2]. The gene contains a conserved dynein light chain domain but is significantly larger than canonical dynein light chain proteins, and is considered an atypical member of the dynein-related protein family[2]. There is currently no evidence indicating it is targeted by existing drugs or used as a biomarker in clinical settings[1][2][9].

Other names

C1orf125FLJ32940axonemal dynein light chain domain containing 1AXDND1