Target intelligence / Profile preview

Azoximer Bromide

Molecular classification
Synthetic cationic polymer, Immunomodulator, Adjuvant
01

Overview

Azoximer bromide, marketed as Polyoxidonium, is a high-molecular-weight synthetic cationic polymer used primarily as an immunomodulator and adjuvant. It is designed to enhance the body's immune response against infections and has additional detoxifying and antioxidant properties. It acts broadly on both innate and adaptive immunity by enhancing cellular responses while also providing antioxidant/detoxicating benefits. Its use spans infection prevention/treatment through support during cancer therapies but requires more robust clinical validation per international standards before widespread adoption outside its current markets.

Other names
Polyoxidonium
02

Mechanism of action

Stimulates innate and adaptive immunity, activates NF-kB pathway, and modulates hydrogen peroxide concentrations within cells leading to antioxidant and detoxifying effects.

03

Biological functions

Immune response modulationPhagocytosis stimulationNK cell activation and degranulationT-cell proliferationDendritic cell maturationNF-kB pathway activationDetoxificationAntioxidant
04

Disease associations

InfectionSecondary immunodeficiencyOncology supportInflammation
05

Safety considerations

Insufficient validation by large-scale double-blind randomized controlled trials according to modern evidence-based standards.Specialist consultation advised before use due to contraindications.
06

Interacting drugs

Influenza vaccines

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