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B and T Lymphocyte Attenuator (None)
- Target
- None
- Molecular classification
- CD28 Ig-superfamily, Receptor, Immunoglobulin superfamily receptor
01
Overview
B and T lymphocyte attenuator (BTLA), also known as CD272, is an immunomodulatory receptor belonging to the CD28 immunoglobulin superfamily. It is widely expressed on immune cells and functions as a co-inhibitory receptor, downregulating immune responses. BTLA interacts with HVEM, leading to ITIM/ITSM phosphorylation and recruitment of phosphatases like SHP-1/SHP-2, which inhibit lymphocyte activation. It plays roles in immune tolerance, infection, and innate immune suppression, making it a potential therapeutic target, particularly in cancer immunotherapy and autoimmune diseases.
- Other names
- BTLACD272
02
Mechanism of action
Inhibition of lymphocyte activation through ITIM/ITSM signaling; recruitment of SHP-1/SHP-2 phosphatases
03
Biological functions
Immune inhibitionMaintenance of immune toleranceRegulation during infectionSuppression of innate responsesNegative regulation of lymphocyte activity
04
Disease associations
CancerAutoimmune diseasesInfectionInflammation
05
Safety considerations
Potential for immune-related adverse events with checkpoint blockade strategiesComplex role in immune regulation requires careful consideration of context-dependent effects
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