B-box and SPRY domain-containing protein (BSPRY)

B-box and SPRY domain-containing protein (BSPRY) is a human protein containing both a B-box zinc finger domain and a SPRY domain. The SPRY domain is recognized as a protein–protein interaction module common among a wide family of proteins, regulating various biological pathways—predominantly involved in innate and adaptive immunity, and some forms of cellular signaling[1][2]. However, BSPRY as an individual gene/protein does not appear in major drug target or receptor databases, nor is there evidence it is a receptor, enzyme, transporter, transcription factor, or other recognized therapeutic target. No concrete biological functions, disease associations, or pharmacological interactions are documented for BSPRY specifically in the currently accessible scientific literature or databases[1][2]. This suggests BSPRY refers to a **protein of unclear function and significance**, not a validated therapeutic target or canonical receptor. **Key points:** - BSPRY is the standard protein/gene name for a protein with B-box and SPRY domains. - The SPRY domain family is a diverse, structurally conserved group involved in various protein–protein interactions, generally with immune system roles[1][2]. - There is no evidence that BSPRY is a receptor, drug target, or functionally characterized disease gene. - No known drugs bind or target BSPRY, and it is not recognized as a clinical biomarker. If your goal is to map to validated receptors, enzymes, or classic therapeutic targets, BSPRY would **not** fit these categories. Its function, druggability, and clinical relevance remain unclear at this time, despite the SPRY domain’s broader significance in biology[1][2].

Other names

BSPRYFLJ20150zetin 1B box and SPRY domain-containing proteinB-box and SPRY-domain containing protein