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Target intelligence / Profile preview
Tumor Necrosis Factor Ligand Superfamily Member 13B (BAFF)
- Target
- BAFF
- Molecular classification
- Cytokine, TNF Ligand Superfamily Member
01
Overview
Tumor necrosis factor ligand superfamily member 13B (BAFF) is a cytokine crucial for B cell development, survival, and function. It interacts with receptors TACI, BCMA, and BAFFR to activate NF-kappa-B signaling, promoting B cell survival and regulating humoral immunity. Dysregulation of BAFF is implicated in autoimmune diseases.
- Other names
- B-cell activating factorB lymphocyte stimulatorCD257Dendritic cell-derived TNF-like moleculeTALL-1TNF and APOL-related leukocyte expressed ligand 1
02
Mechanism of action
BAFF inhibitor
03
Biological functions
B cell developmentB cell survivalHumoral immunity regulationNF-kappa-B signaling
04
Disease associations
Systemic lupus erythematosusSjögren syndromeAutoimmune diseasesImmunodeficiency
05
Safety considerations
Increased risk of infectionPotential for immunodeficiency
06
Interacting drugs
Belimumab
07
Biomarkers
BAFF levels in serumAntibody levels
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