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Target intelligence / Profile preview
B-cell Activating Factor Receptor (BAFF-R)
- Target
- BAFF-R
- Molecular classification
- Type III transmembrane protein, TNF receptor superfamily, Receptor
01
Overview
The BAFF receptor (BAFF-R/TNFRSF13C) is an essential surface molecule on maturing/mature human B lymphocytes that mediates critical pro-survival signals upon engagement with its unique ligand—BAFF. It orchestrates downstream pathways such as NF-kappaB2 and PI3K/AKT/mTOR that collectively ensure proper development, metabolic fitness, longevity, differentiation potential—and thus effective humoral immunity—of peripheral naive/memory/plasma cell populations. Dysfunctional signaling through this axis underlies several immunodeficiencies as well as autoimmunity when dysregulated.
- Other names
- TNFRSF13C
02
Mechanism of action
Agonism of BAFF-R leads to activation of NF-kappaB2 and PI3K/AKT/mTOR signaling pathways
03
Biological functions
Signal transductionB cell survivalB cell maturationMaintenance of peripheral mature B cellsGerminal center formationImmune response
04
Disease associations
Autoimmune diseasesImmunodeficiency syndromes
05
Safety considerations
Dysregulation implicated in autoimmune diseases due to abnormal germinal center formation or excessive survival signals leading to autoreactive clones.
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