B-cell acute lymphoblastic leukemia-expressed protein (BLACE)

B-cell acute lymphoblastic leukemia-expressed protein (BLACE) is a gene highly and specifically expressed in B-cell acute lymphoblastic leukemia (B-ALL), with little to no expression in mature B-lymphocytes. Transcriptomic studies suggest its expression is regulated at the promoter level, including by TAL1 transcription factor binding, and it may play a role in leukemogenesis via interactions with the transcriptional machinery. BLACE has emerged as a potential therapeutic target and biomarker for B-ALL, although its precise molecular function, protein classification, and potential as a drug target remain to be fully elucidated. BLACE is distinct from conventional receptors, kinases, or transporters; it may represent a novel non-coding RNA or protein with relevance to B-ALL diagnosis and targeted therapy. TAL1 transcription factor binding at the BLACE promoter suggests a transcriptional regulatory axis that may be exploitable for therapeutic intervention in B-ALL. No interacting drugs or safety data are available, as clinical targeting of BLACE is still under investigation.

Other names

BLACEB cell acute lymphoblastic leukemia expressedB-cell acute lymphoblastic leukemia-expressed protein