B-cell and T-cell antigen receptors recognizing Invasion plasmid antigen B, Invasion plasmid antigen C, and Lipopolysaccharide epitopes (BCR/TCR (IpaB/IpaC/LPS))

The B-cell and T-cell antigen receptors recognizing Invasion plasmid antigen B (IpaB), Invasion plasmid antigen C (IpaC), and Lipopolysaccharide (LPS) epitopes are the primary components of the adaptive immune system responsible for identifying and responding to Shigella infections (Levine et al., 2007, PMID: 17554611). IpaB and IpaC are essential translocator proteins of the Shigella Type III Secretion System (T3SS), which the pathogen uses to invade host cells and escape the endocytic vacuole (Picking et al., 2005, PMID: 15659681). Lipopolysaccharide (LPS) is the major surface-exposed antigen and a key determinant of serotype-specific immunity (Oaks and Turbyfill, 2006, PMID: 16501136). B-cell receptors (BCRs) bind these epitopes to initiate the production of neutralizing antibodies, particularly mucosal IgA, while T-cell receptors (TCRs) recognize processed Ipa peptides to trigger cellular immune responses and cytokine release. These receptors are the functional targets of vaccine candidates like Invaplex and various live-attenuated Shigella strains, which aim to elicit protective memory responses (Venkatesan et al., 2001, PMID: 11544353). Effective engagement of these receptors is critical for preventing shigellosis, a major cause of global morbidity and mortality due to severe diarrheal disease.

Other names

Shigella-specific antigen receptors (Levine et al., 2007)Ipa-specific T-cell receptor (Picking et al., 2005)Ipa-specific B-cell receptorLPS-specific B-cell receptor (Oaks and Turbyfill, 2006)Anti-Shigella immune receptors

Induction of adaptive mucosal and systemic immunity through the activation of antigen-specific B and T lymphocytes to neutralize bacterial virulence factors and O-antigens (Venkatesan et al., 2001).