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Target intelligence / Profile preview
B-cell lymphoma 2 mRNA (BCL-2 mRNA)
- Target
- BCL-2 mRNA
- Molecular classification
- mRNA, Non-coding RNA, Transcript
01
Overview
B-cell lymphoma 2 (BCL-2) mRNA is the messenger RNA transcribed from the BCL-2 gene, encoding the BCL-2 protein, a key anti-apoptotic regulator. Overexpression of BCL-2 mRNA and its encoded protein is implicated in various cancers, particularly lymphomas, leading to increased cell survival and resistance to chemotherapy. It is a therapeutic target for antisense oligonucleotides and small molecule inhibitors to promote apoptosis in cancer cells.
- Other names
- BCL2 mRNABcl-2 mRNA
02
Mechanism of action
Antisense oligonucleotides reduce intracellular levels of BCL-2 mRNA; small molecule inhibitors target the BCL-2 protein.
03
Biological functions
Regulation of apoptosisCell survivalTranscriptional template
04
Disease associations
CancerLymphomaChemoresistanceFollicular lymphoma (FL)Diffuse large B-cell lymphoma (DLBCL)Chronic lymphocytic leukemia (CLL)Acute lymphocytic leukemia (ALL)
05
Safety considerations
On-target toxicityResistance development
06
Interacting drugs
Oblimersen sodium
2 more in the full profile.
07
Biomarkers
BCL-2 mRNA expression levelst(14;18) translocation
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