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Target intelligence / Profile preview
B-cell lymphoma-w protein (None)
- Target
- None
- Molecular classification
- Anti-apoptotic protein, Bcl-2 family
01
Overview
The B-cell lymphoma-w protein (BCL-W) is a member of the BCL-2 family, a key regulator of apoptosis. BCL-W acts as an antiapoptotic factor promoting cell survival by inhibiting programmed cell death. Overexpression is observed in lymphomas such as Burkitt Lymphoma and Diffuse Large B Cell Lymphoma, which correlates with decreased patient survival rates and resistance against therapies targeting other antiapoptotic members. MYC regulates expression levels. Potential therapeutic strategies aim at inhibiting or downregulating BCL-W to sensitize tumor cells to apoptosis-inducing treatments.
- Other names
- Bcl-w
02
Mechanism of action
Currently no widely available direct inhibitors; research focuses on developing strategies to inhibit or downregulate BCL-W
03
Biological functions
Inhibition of apoptosisCell survival
04
Disease associations
CancerLymphoma (Burkitt Lymphoma, Diffuse Large B Cell Lymphoma)Tumorigenesis
05
Safety considerations
Inhibition may disrupt normal cell survival mechanismsPotential for off-target effects
06
Biomarkers
Elevated BCL-W levels in Burkitt Lymphoma and Diffuse Large B Cell Lymphoma
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