B cell receptor on Norwalk virus GI.1-specific B cells (BCR (GI.1-specific))

The B cell receptor (BCR) on Norwalk virus GI.1-specific B cells is a membrane-bound immunoglobulin that specifically recognizes the VP1 capsid protein of the Norwalk virus, the prototype strain of Genogroup I noroviruses (Lindesmith et al., 2011, J. Virol.). This receptor plays a critical role in the adaptive immune response by mediating the recognition of viral antigens and initiating the activation, proliferation, and differentiation of B cells into antibody-secreting plasma cells (Parra et al., 2017, Rev. Med. Virol.). In the context of norovirus infection, which causes acute gastroenteritis, these BCRs are the primary targets for vaccine-induced immunity, where virus-like particles (VLPs) are used to stimulate the production of neutralizing antibodies (Atmar et al., 2011, NEJM). Research into these specific BCRs has led to the isolation of potent monoclonal antibodies that can block the virus from binding to its cellular receptors, such as histo-blood group antigens (HBGAs) (Shanker et al., 2011, J. Virol.). Understanding the repertoire and binding affinity of these receptors is essential for developing broadly protective vaccines against diverse norovirus genotypes (Takeda Pharmaceutical Company, 2023). Therapeutic strategies often focus on eliciting a robust response from B cells expressing these receptors to ensure long-term mucosal and systemic protection.

Other names

Norwalk virus GI.1-specific B-cell receptorNV GI.1 BCRGI.1-specific B-cell receptorNorovirus GI.1 B-cell receptor

Antigen-mediated activation of B cells through BCR signaling, where the binding of the Norwalk virus VP1 protein or virus-like particles (VLPs) triggers the Ig-alpha/Ig-beta (CD79a/CD79b) complex, leading to B cell differentiation into memory B cells and plasma cells.