B-cell receptor repertoire specific for rotavirus VP7 and VP4 P epitopes (BCR-RV-VP7/VP4)

The B-cell receptor (BCR) repertoire specific for rotavirus VP7 and VP4 P epitopes refers to the diverse collection of immunoglobulins expressed by B cells that recognize the two primary neutralization antigens on the rotavirus outer capsid. VP7 is a glycoprotein (G-type) and VP4 is a protease-cleaved protein (P-type) that together mediate viral attachment and entry into host intestinal cells (Crawford et al., 2017, Nature Reviews Disease Primers). This repertoire is a critical component of the adaptive immune system's defense against rotavirus infection, as specific BCRs and their secreted antibody counterparts can neutralize the virus by blocking its ability to bind to cellular receptors or by preventing the conformational changes required for membrane penetration (Desselberger, 2014, Virus Research). Characterization of this repertoire is vital for understanding natural immunity and for the development of vaccines, such as Rotarix and RotaTeq, which aim to induce a robust and diverse population of these B cells (Angel et al., 2007, Journal of Infectious Diseases). Furthermore, identifying high-affinity BCR sequences from this repertoire allows for the engineering of monoclonal antibodies that can be used for passive immunization or as diagnostic tools (Nair et al., 2017, Journal of Virology).

Other names

Rotavirus-specific B-cell receptor repertoireAnti-VP7/VP4 antibody repertoireRotavirus-specific BCRsNeutralizing antibody repertoire against rotavirus

Neutralization of viral particles by binding to VP7 and VP4 proteins, thereby blocking viral attachment to host cell receptors and preventing membrane penetration.