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Target intelligence / Profile preview
B-cell-specific Moloney murine leukemia virus insertion site 1 protein (BMI-1)
- Target
- BMI-1
- Molecular classification
- Transcription factor, Polycomb group (PcG) protein
01
Overview
BMI-1 is a transcriptional repressor and a member of the polycomb group (PcG) family of proteins. It plays a critical role in regulating cell proliferation, apoptosis, and stem cell self-renewal by repressing genes like p16INK4a and p14ARF. BMI-1 is overexpressed in various cancers, including gastric carcinoma and salivary adenoid cystic carcinoma, where it is associated with increased tumor aggressiveness, invasion, and metastasis. It represents a potential therapeutic target for cancer treatment.
- Other names
- BMI1Bmi1 proto-oncogene, stem cell factor
02
Mechanism of action
Inhibition of BMI-1 to promote cell cycle arrest and apoptosis, primarily through upregulation of tumor suppressor genes such as p16INK4a and p14ARF.
03
Biological functions
Transcriptional repressionCell proliferationApoptosisCell cycle regulationStem cell self-renewalSenescence prevention
04
Disease associations
CancerGastric carcinomaSalivary adenoid cystic carcinomaColorectal cancerBreast cancer
05
Safety considerations
Potential for off-target effects due to the widespread role of BMI-1 in normal stem cell function.Development of resistance to BMI-1 inhibitors.
06
Biomarkers
BMI-1 expression level (tumor invasion and metastasis prediction)Ki-67 positivityBcl-2 positivity
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