B cells and selected myeloid cells

The term B cells and selected myeloid cells refers to a broad cellular distribution rather than a single molecular target. B cells are the primary mediators of the adaptive humoral immune response, responsible for producing antibodies and presenting antigens to T cells. Selected myeloid cells, which include monocytes, macrophages, and dendritic cells, serve as critical components of the innate immune system and act as professional antigen-presenting cells. In therapeutic contexts, drugs often target proteins expressed across these populations, such as Bruton's tyrosine kinase (BTK) or CD74, to treat B-cell malignancies and autoimmune disorders. Modulating these cell types allows for the control of both antibody-mediated and inflammatory pathways in various diseases.

Other names

B-cell and myeloid cell populationsB-lymphocytes and myeloid lineage cells

Inhibition of B-cell receptor signaling, depletion of B-cell populations, modulation of antigen presentation, and inhibition of pro-inflammatory cytokine release.