Target intelligence / Profile preview

B-lymphocyte cell adhesion molecule (CD22) (CD22)

Target: CD22
Molecular classification: Cell adhesion molecule, Lectin, Sialic acid-binding Ig-like lectin

Overview

B-lymphocyte cell adhesion molecule, known as CD22, is a B lineage-specific cell surface glycoprotein encoded by the human CD22 gene, with a molecular weight of approximately 95 kDa and 847 amino acids. It functions in B cell adhesion to other cells, including interactions with CD45RO on T cells and CD75 (alpha 2-6 sialyltransferase) on B cells, and regulates B cell antigen receptor signaling. CD22 is directly involved in cognate B-T cell interactions and B cell-B cell adhesion processes.

Other names: CD22B-cell receptor CD22Sialic acid-binding Ig-like lectin 2 (Siglec-2)

Biological functions

Cell adhesionAntigen receptor signaling regulationB cell-T cell interactionB cell activation regulation

Disease associations

Autoimmune disease (e.g., multiple sclerosis)

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