Target intelligence / Profile preview

B lymphoid tyrosine kinase (BLK)

Target: BLK
Molecular classification: Enzyme, Non-receptor protein tyrosine kinase, Src family kinases

Overview

B lymphoid tyrosine kinase (BLK) is a non-receptor tyrosine kinase belonging to the Src family, primarily expressed in B lymphocytes. It plays a crucial role in B-cell receptor (BCR) signaling and development. BLK functions downstream of the BCR, phosphorylating ITAMs and initiating intracellular signaling cascades essential for B cell activation and differentiation. Beyond immune function, BLK stimulates insulin synthesis and secretion. It also acts as an oncogene in certain cancers, making it a therapeutic target for drugs like dasatinib.

Other names: Tyrosine-protein kinase BLK

Mechanism of action

Inhibition of BLK kinase activity

Biological functions

Signal transductionB-cell receptor (BCR) signalingB cell developmentInsulin synthesis and secretion

Disease associations

CancerCutaneous T-cell lymphoma (CTCL)

Interacting drugs

Dasatinib

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