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Target intelligence / Profile preview
B-Raf family (RAF)
- Target
- RAF
- Molecular classification
- Serine/threonine kinase, Protein kinase, Tyrosine kinase-like (TKL) group, Proto-oncogene
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Overview
The B-Raf family includes ARAF, BRAF, and CRAF (RAF1), which are serine/threonine kinases that play a central role in the RAS-RAF-MEK-ERK signaling pathway. This pathway regulates cell growth, differentiation, survival, and development. Dysregulation, particularly mutations in BRAF, is a major contributor to human cancer. Germline mutations in BRAF or CRAF can cause developmental syndromes known as "RASopathies".
- Other names
- ARAFBRAFCRAFRAF1c-RafRaf-1v-Raf murine sarcoma viral oncogene homolog B
02
Mechanism of action
Inhibition of BRAF kinase activity
03
Biological functions
Signal transductionCell growthCell differentiationCell survivalApoptosisRegulation of MAPK/ERK pathway
04
Disease associations
CancerMelanomaThyroid cancerColorectal cancerNon-Hodgkin lymphomaRASopathiesNoonan syndromeCardiofaciocutaneous syndrome
05
Safety considerations
Resistance to BRAF inhibitorsParadoxical activation of MAPK pathway in some contextsToxicity associated with kinase inhibitors
06
Interacting drugs
Vemurafenib
1 more in the full profile.
07
Biomarkers
BRAF V600E mutation
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